CHSY1

Across TCGA cell cohorts, CHSY1 mutation is significantly associated with the mutation status of many other genes, with 3,965 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CHSY1-associated genes across cancer lineages are PLD2, PCDHA13, and C20orf194. Each is linked with CHSY1 in more than 3 cancer types. Because this analysis shows association rather than direction, both CHSY1-to-partner and partner-to-CHSY1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PLD2 grouped by CHSY1-low versus CHSY1-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHSY1→partner) and Y-score (partner→CHSY1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	PLD2 →	+6.169	+6.169	<.001	<.001	1	4
LARGE_INTESTINE	PCDHA13 →	+1.552	+3.495	.005	.005	1	4
LARGE_INTESTINE	C20orf194 →	+2.407	+2.886	.008	.008	1	3
BLOOD_Lymphoma	ESF1 →	+4.584	+4.584	.007	.007	1	3
BLOOD_Lymphoma	LHX5 →	+4.584	+4.584	.007	.007	1	3
BLOOD_Lymphoma	TASP1 →	+4.584	+4.584	.007	.007	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,965 associations by consensus.

PLD2 by CHSY1 expression — BLOOD_Lymphoma

Explore this box plot interactively →