CHST6

Across TCGA patient cohorts, CHST6 mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CHST6-associated genes across cancer lineages are Fibronectin, Lck, and ATM. Each is linked with CHST6 in more than 3 cancer types. Because this analysis shows association rather than direction, both CHST6-to-partner and partner-to-CHST6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Fibronectin grouped by CHST6-low versus CHST6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHST6→partner) and Y-score (partner→CHST6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Fibronectin →	-0.431	-3.392	<.001	<.001	3	2
UCEC	Lck →	+0.278	+1.847	<.001	.008	3	2
UCEC	ATM →	-0.543	-2.687	.001	.005	3	2
UCEC	Caspase-7-cleavedD198 →	+1.338	+2.247	<.001	.001	1	4
UCEC	Caspase-8 →	-0.190	-2.673	.039	.005	3	2
COAD	DJ-1 →	+0.212	+2.815	.038	.036	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

Fibronectin by CHST6 expression — UCEC

Explore this box plot interactively →