CHST6

Across TCGA cell cohorts, CHST6 mutation is significantly associated with the RNA expression of many other genes, with 41 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CHST6-associated genes across cancer lineages are ARGFX, OR2M5, and PRM3. Each is linked with CHST6 in more than 1 cancer types. Because this analysis shows association rather than direction, both CHST6-to-partner and partner-to-CHST6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ARGFX grouped by CHST6-low versus CHST6-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHST6→partner) and Y-score (partner→CHST6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	ARGFX →	+0.080	+4.087	<.001	.009	3	1
CNS	OR2M5 →	+0.044	+5.321	<.001	.005	3	1
CNS	PRM3 →	+0.178	+5.754	<.001	.002	3	1
CNS	HELT →	+0.055	+5.321	<.001	.005	3	1
LARGE_INTESTINE	MAGEB4 →	+0.014	+4.000	<.001	<.001	3	1
LARGE_INTESTINE	CPO →	+0.166	+3.514	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

ARGFX by CHST6 expression — URINARY_TRACT

Explore this box plot interactively →