CHST4

Across TCGA patient cohorts, CHST4 mutation is significantly associated with the RNA expression of many other genes, with 2,741 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CHST4-associated genes across cancer lineages are OR8K1, JPT1, and NCAPD2P1. Each is linked with CHST4 in more than 1 cancer types. Because this analysis shows association rather than direction, both CHST4-to-partner and partner-to-CHST4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR8K1 grouped by CHST4-low versus CHST4-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHST4→partner) and Y-score (partner→CHST4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	OR8K1 →	+0.151	+5.124	<.001	.008	3	2
SKCM	JPT1 →	+0.530	+2.006	<.001	.001	3	2
UCEC	NCAPD2P1 →	+0.627	+3.572	<.001	.002	3	2
LUSC	RNU5D-1 →	+0.722	+3.898	<.001	.004	3	2
LUSC	MIR1231 →	+0.310	+4.191	<.001	.009	3	2
LUSC	MTND1P28 →	+0.054	+4.038	.002	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,741 associations by consensus.

OR8K1 by CHST4 expression — HNSC

Explore this box plot interactively →