CHST4

Across TCGA cell cohorts, CHST4 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CHST4-associated genes across cancer lineages are MCHR2, OR10W1, and ITLN1. Each is linked with CHST4 in more than 1 cancer types. Because this analysis shows association rather than direction, both CHST4-to-partner and partner-to-CHST4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MCHR2 grouped by CHST4-low versus CHST4-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHST4→partner) and Y-score (partner→CHST4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	MCHR2 →	+0.018	+4.029	.004	.009	3	2
LARGE_INTESTINE	OR10W1 →	+0.012	+3.240	<.001	.004	3	1
LARGE_INTESTINE	ITLN1 →	+1.226	+3.339	<.001	.007	3	1
LARGE_INTESTINE	OR10Q1 →	+0.146	+3.505	<.001	<.001	3	1
LARGE_INTESTINE	FREM3 →	+0.085	+3.639	.005	<.001	3	1
LARGE_INTESTINE	TMEM72 →	+0.168	+3.584	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

MCHR2 by CHST4 expression — OVARY

Explore this box plot interactively →