CHST4

Across TCGA cell cohorts, CHST4 mutation is significantly associated with the mutation status of many other genes, with 2,590 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CHST4-associated genes across cancer lineages are TUSC3, TET2, and CDC42BPG. Each is linked with CHST4 in more than 3 cancer types. Because this analysis shows association rather than direction, both CHST4-to-partner and partner-to-CHST4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TUSC3 grouped by CHST4-low versus CHST4-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHST4→partner) and Y-score (partner→CHST4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	TUSC3 →	+5.066	+4.502	.007	.007	1	4
BLOOD_Leukemia	TET2 →	+3.309	+4.794	.002	.002	1	4
BLOOD_Lymphoma	CDC42BPG →	+3.169	+4.601	.003	.003	1	4
LARGE_INTESTINE	CCDC66 →	+2.544	+2.793	.003	.003	1	4
BLOOD_Leukemia	PITPNM2 →	+2.779	+4.326	.006	.006	1	3
SKIN	RHBDD3 →	+4.392	+4.392	.009	.009	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,590 associations by consensus.

TUSC3 by CHST4 expression — SOFT_TISSUE

Explore this box plot interactively →