CHST3

Across TCGA patient cohorts, CHST3 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CHST3-associated genes across cancer lineages are GSK-3a-b_pS21_S9, JNK2, and MEK1. Each is linked with CHST3 in more than 1 cancer types. Because this analysis shows association rather than direction, both CHST3-to-partner and partner-to-CHST3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GSK-3a-b_pS21_S9 grouped by CHST3-low versus CHST3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHST3→partner) and Y-score (partner→CHST3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GSK-3a-b_pS21_S9 →	+0.440	+2.321	.040	.035	3	1
UCEC	JNK2 →	+0.249	+2.834	.012	.034	3	1
UCEC	MEK1 →	+0.485	+3.169	.008	.019	3	1
UCEC	Annexin-1 →	+0.800	+3.019	.002	.019	3	1
UCEC	S6_pS240_S244 →	+0.456	+2.321	.025	.035	3	1
UCEC	Tuberin →	+0.337	+2.321	.012	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

GSK-3a-b_pS21_S9 by CHST3 expression — UCEC

Explore this box plot interactively →