CHST3

Across TCGA cell cohorts, CHST3 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,839 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible CHST3-associated GO terms across cancer lineages are Positive regulation of cell-substrate adhesion, Regulation of cell-substrate junction organization, and Actin filament depolymerization. Each is linked with CHST3 in more than 12 cancer types. Because this analysis shows association rather than direction, both CHST3-to-partner and partner-to-CHST3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of cell-substrate adhesion grouped by CHST3-low versus CHST3-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CHST3→partner) and Y-score (partner→CHST3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of cell-substrate adhesion →	+0.177	+1.592	<.001	<.001	3	13
BONE	Regulation of cell-substrate junction organization →	+0.203	+1.781	<.001	<.001	3	13
BONE	Actin filament depolymerization →	+0.259	+1.971	<.001	<.001	3	13
BONE	Positive regulation of stress fiber assembly →	+0.217	+1.566	<.001	<.001	3	13
BONE	Positive regulation of plasma membrane repair →	+0.367	+1.869	<.001	<.001	3	13
BONE	Regulation of hippo signaling →	+0.077	+1.408	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,839 associations by consensus.

Positive regulation of cell-substrate adhesion by CHST3 expression — BONE

Explore this box plot interactively →