CHST2

Across TCGA patient cohorts, CHST2 mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CHST2-associated genes across cancer lineages are ERK2, Ku80, and Notch1. Each is linked with CHST2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CHST2-to-partner and partner-to-CHST2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by CHST2-low versus CHST2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHST2→partner) and Y-score (partner→CHST2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.207	+1.440	.001	.024	3	2
UCEC	Ku80 →	+0.260	+2.472	.001	<.001	3	2
UCEC	Notch1 →	+0.115	+1.736	.018	.007	3	2
UCEC	PCNA →	+0.266	+2.070	<.001	.001	3	2
UCEC	Annexin_VII →	-0.117	-1.736	.015	.007	3	2
UCEC	BRD4 →	+0.207	+3.169	.029	.018	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

ERK2 by CHST2 expression — UCEC

Explore this box plot interactively →