CHST2

Across TCGA cell cohorts, CHST2 mutation is significantly associated with the RNA expression of many other genes, with 133 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CHST2-associated genes across cancer lineages are PTH, WFDC13, and MROH2B. Each is linked with CHST2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CHST2-to-partner and partner-to-CHST2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PTH grouped by CHST2-low versus CHST2-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHST2→partner) and Y-score (partner→CHST2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	PTH →	+0.013	+4.662	<.001	.003	3	1
BLOOD_Lymphoma	WFDC13 →	+0.125	+3.927	<.001	.004	3	1
BLOOD_Lymphoma	MROH2B →	+0.069	+4.058	<.001	.009	3	1
BLOOD_Lymphoma	DEFB124 →	+0.135	+3.927	<.001	.004	3	1
BLOOD_Lymphoma	SCGB1C1 →	+0.136	+5.129	<.001	<.001	3	1
BLOOD_Lymphoma	OR56A5 →	+0.063	+3.927	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 133 associations by consensus.

PTH by CHST2 expression — BLOOD_Lymphoma

Explore this box plot interactively →