CHST15

Across TCGA patient cohorts, CHST15 mutation is significantly associated with the RNA expression of many other genes, with 5,921 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CHST15-associated genes across cancer lineages are CBY1P1, RN7SL638P, and THAP12P4. Each is linked with CHST15 in more than 3 cancer types. Because this analysis shows association rather than direction, both CHST15-to-partner and partner-to-CHST15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CBY1P1 grouped by CHST15-low versus CHST15-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHST15→partner) and Y-score (partner→CHST15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	CBY1P1 →	+0.106	+4.706	.008	.007	3	4
BRCA	RN7SL638P →	+0.209	+5.409	<.001	.005	3	4
LGG	THAP12P4 →	+0.025	+5.760	<.001	.003	3	3
SKCM	PRKY →	+0.770	+2.328	.003	<.001	3	3
SKCM	PALM →	-1.010	-2.869	.001	.001	3	3
COAD	H2AC14 →	+1.546	+3.720	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,921 associations by consensus.

CBY1P1 by CHST15 expression — LUSC

Explore this box plot interactively →