CHST15

Across TCGA patient cohorts, CHST15 mutation is significantly associated with the total protein of many other genes, with 56 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CHST15-associated genes across cancer lineages are INPP4B, ATM, and 14-3-3_beta. Each is linked with CHST15 in more than 2 cancer types. Because this analysis shows association rather than direction, both CHST15-to-partner and partner-to-CHST15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INPP4B grouped by CHST15-low versus CHST15-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHST15→partner) and Y-score (partner→CHST15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	INPP4B →	-0.246	-1.736	.017	.006	3	3
UCEC	ATM →	-0.545	-2.401	<.001	.002	3	3
UCEC	14-3-3_beta →	-0.079	-2.195	.013	.009	3	2
UCEC	eIF4E →	+0.181	+1.523	.007	.008	3	2
UCEC	MEK1 →	+0.452	+2.378	<.001	<.001	3	2
UCEC	TFRC →	+0.547	+1.777	.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 56 associations by consensus.

INPP4B by CHST15 expression — UCEC

Explore this box plot interactively →