CHST14

Across TCGA patient cohorts, CHST14 mutation is significantly associated with the RNA expression of many other genes, with 1,051 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CHST14-associated genes across cancer lineages are RN7SKP181, RNU4-88P, and RNA5SP416. Each is linked with CHST14 in more than 1 cancer types. Because this analysis shows association rather than direction, both CHST14-to-partner and partner-to-CHST14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SKP181 grouped by CHST14-low versus CHST14-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHST14→partner) and Y-score (partner→CHST14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RN7SKP181 →	+0.168	+5.436	<.001	.005	3	2
BLCA	RNU4-88P →	+0.348	+7.640	<.001	.009	3	2
UCEC	RNA5SP416 →	+0.415	+2.224	.004	.009	3	2
UCEC	MTUS2-AS1 →	+0.238	+3.069	.001	<.001	3	1
UCEC	ARID3B →	+0.545	+3.601	<.001	.001	3	1
UCEC	VWA1 →	-1.087	-3.437	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,051 associations by consensus.

RN7SKP181 by CHST14 expression — SKCM

Explore this box plot interactively →