CHST14

Across TCGA patient cohorts, CHST14 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CHST14-associated genes across cancer lineages are EGFR_pY1068, GAPDH, and GATA6. Each is linked with CHST14 in more than 1 cancer types. Because this analysis shows association rather than direction, both CHST14-to-partner and partner-to-CHST14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by CHST14-low versus CHST14-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHST14→partner) and Y-score (partner→CHST14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.244	-3.000	.037	.036	3	1
UCEC	GAPDH →	+0.546	+3.169	.029	.019	3	1
UCEC	GATA6 →	-0.179	-2.985	.013	.034	3	1
UCEC	JNK2 →	+0.336	+3.026	<.001	.018	3	1
UCEC	MEK1 →	+0.521	+3.459	.002	.005	3	1
UCEC	p21 →	+0.176	+2.820	.049	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

EGFR_pY1068 by CHST14 expression — UCEC

Explore this box plot interactively →