CHST10

Across TCGA patient cohorts, CHST10 mutation is significantly associated with the total protein of many other genes, with 59 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CHST10-associated genes across cancer lineages are Shc_pY317, eEF2, and ERK2. Each is linked with CHST10 in more than 2 cancer types. Because this analysis shows association rather than direction, both CHST10-to-partner and partner-to-CHST10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Shc_pY317 grouped by CHST10-low versus CHST10-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHST10→partner) and Y-score (partner→CHST10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Shc_pY317 →	-0.253	-3.000	<.001	<.001	3	3
UCEC	eEF2 →	+0.368	+2.247	.005	.001	3	2
UCEC	ERK2 →	+0.191	+2.584	.006	.010	3	2
UCEC	JNK_pT183_Y185 →	-0.221	-3.906	<.001	<.001	3	2
UCEC	JNK2 →	+0.300	+2.736	<.001	<.001	3	2
UCEC	MEK1 →	+0.422	+3.087	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 59 associations by consensus.

Shc_pY317 by CHST10 expression — UCEC

Explore this box plot interactively →