CHST1

Across TCGA patient cohorts, CHST1 mutation is significantly associated with the RNA expression of many other genes, with 4,457 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CHST1-associated genes across cancer lineages are CDCA2, SHLD3, and ERI1. Each is linked with CHST1 in more than 3 cancer types. Because this analysis shows association rather than direction, both CHST1-to-partner and partner-to-CHST1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CDCA2 grouped by CHST1-low versus CHST1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHST1→partner) and Y-score (partner→CHST1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CDCA2 →	+0.844	+2.378	<.001	<.001	3	4
UCEC	SHLD3 →	+0.499	+2.186	<.001	.001	3	4
COAD	ERI1 →	+0.549	+2.713	.002	.003	3	4
COAD	RASSF1 →	+0.466	+3.479	<.001	.002	3	4
UCEC	PDP2 →	+0.406	+2.534	<.001	<.001	3	4
UCEC	RIOK2 →	+0.372	+2.389	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,457 associations by consensus.

CDCA2 by CHST1 expression — UCEC

Explore this box plot interactively →