CHST1

Across TCGA patient cohorts, CHST1 mutation is significantly associated with the total protein of many other genes, with 56 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CHST1-associated genes across cancer lineages are Caspase-7-cleavedD198, 4E-BP1, and MSH2. Each is linked with CHST1 in more than 2 cancer types. Because this analysis shows association rather than direction, both CHST1-to-partner and partner-to-CHST1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by CHST1-low versus CHST1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHST1→partner) and Y-score (partner→CHST1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.664	+1.604	.001	.021	3	3
UCEC	4E-BP1 →	+0.289	+3.584	.001	.002	3	2
COAD	MSH2 →	-0.263	-2.974	.006	.035	3	2
COAD	C-Raf →	+0.158	+2.356	.013	.017	3	2
UCEC	EGFR_pY1068 →	-0.289	-3.000	<.001	<.001	3	2
UCEC	EGFR →	-0.162	-1.700	.003	.042	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 56 associations by consensus.

Caspase-7-cleavedD198 by CHST1 expression — UCEC

Explore this box plot interactively →