CHST1

Across TCGA cell cohorts, CHST1 mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CHST1-associated genes across cancer lineages are MAGEB4, TBL1Y, and SLC22A24. Each is linked with CHST1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CHST1-to-partner and partner-to-CHST1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAGEB4 grouped by CHST1-low versus CHST1-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHST1→partner) and Y-score (partner→CHST1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	MAGEB4 →	+0.005	+4.643	<.001	.004	3	2
LUNG_NSCLC_LUSC	TBL1Y →	+0.053	+4.643	<.001	.008	3	1
BLOOD_Myeloma	SLC22A24 →	+0.013	+4.807	<.001	.006	3	1
SKIN	HTR3D →	+0.020	+6.022	<.001	.001	3	1
LARGE_INTESTINE	SLC15A5 →	+0.017	+4.415	<.001	.007	3	1
BLOOD_Leukemia	CST11 →	+0.036	+3.762	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

MAGEB4 by CHST1 expression — LUNG_SCLC

Explore this box plot interactively →