Across TCGA patient cohorts, CHRNG mutation is significantly associated with the RNA expression of many other genes, with 1,207 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CHRNG-associated genes across cancer lineages are RNU6-436P, XPO7, and RNA5SP308. Each is linked with CHRNG in more than 2 cancer types. Because this analysis shows association rather than direction, both CHRNG-to-partner and partner-to-CHRNG results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHRNG→partner) and Y-score (partner→CHRNG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RNU6-436P →	+0.271	+5.090	<.001	<.001	3	3
UCEC	XPO7 →	+0.589	+2.343	<.001	.003	3	3
LUSC	RNA5SP308 →	+0.372	+5.148	.003	.002	3	3
UCEC	ZWILCH →	+0.562	+3.716	.002	<.001	3	3
UCEC	NECAP1 →	+0.462	+3.601	.006	.001	3	3
READ	KCND3-AS1 →	+0.218	+5.653	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,207 associations by consensus.

Exploration

CHRNG survival (RNA) · tumor vs normal (RNA) · all CHRNG data types