Across TCGA patient cohorts, CHRNG mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CHRNG-associated genes across cancer lineages are Smad4, EGFR_pY1068, and ERK2. Each is linked with CHRNG in more than 2 cancer types. Because this analysis shows association rather than direction, both CHRNG-to-partner and partner-to-CHRNG results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHRNG→partner) and Y-score (partner→CHRNG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Smad4 →	+0.192	+2.815	.008	.036	3	3
UCEC	EGFR_pY1068 →	-0.283	-2.321	.024	.035	3	2
UCEC	ERK2 →	+0.236	+2.321	.014	.035	3	1
UCEC	INPP4B →	-0.415	-3.446	.010	.005	3	1
UCEC	JNK2 →	+0.320	+2.321	.001	.035	3	1
UCEC	Ku80 →	+0.245	+2.335	.038	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

Exploration

CHRNG survival (RNA) · tumor vs normal (RNA) · all CHRNG data types