CHRND

Across TCGA patient cohorts, CHRND mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CHRND-associated genes across cancer lineages are PKC-b-II_pS660, Caspase-7-cleavedD198, and c-Met_pY1235. Each is linked with CHRND in more than 2 cancer types. Because this analysis shows association rather than direction, both CHRND-to-partner and partner-to-CHRND results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PKC-b-II_pS660 grouped by CHRND-low versus CHRND-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHRND→partner) and Y-score (partner→CHRND) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PKC-b-II_pS660 →	-0.224	-2.222	.034	.010	3	3
UCEC	Caspase-7-cleavedD198 →	+0.745	+1.678	.001	.023	3	3
UCEC	c-Met_pY1235 →	+0.069	+1.678	.015	.023	3	3
SKCM	Chk1 →	+0.353	+3.034	.001	.018	3	3
COAD	p27_pT157 →	+0.161	+2.815	.044	.036	3	2
COAD	RAD51 →	+0.202	+2.815	.019	.036	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

PKC-b-II_pS660 by CHRND expression — UCEC

Explore this box plot interactively →