CHRND

Across TCGA cell cohorts, CHRND mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible CHRND-associated genes across cancer lineages are LCN1, ASB17, and PAPOLB. Each is linked with CHRND in more than 1 cancer types. Because this analysis shows association rather than direction, both CHRND-to-partner and partner-to-CHRND results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LCN1 grouped by CHRND-low versus CHRND-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHRND→partner) and Y-score (partner→CHRND) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	LCN1 →	+0.042	+4.544	.005	.003	3	1
OVARY	ASB17 →	+0.014	+4.222	<.001	.006	3	1
OVARY	PAPOLB →	+0.015	+3.791	<.001	.007	3	1
LUNG_SCLC	G6PC →	+0.323	+4.269	<.001	.005	3	1
LUNG_SCLC	CST2 →	+0.051	+4.817	<.001	.001	3	1
LUNG_SCLC	FBXO39 →	+0.019	+5.169	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

LCN1 by CHRND expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →