CHRNB1

Across TCGA patient cohorts, CHRNB1 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CHRNB1-associated genes across cancer lineages are Caspase-7-cleavedD198, eEF2, and EGFR_pY1068. Each is linked with CHRNB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CHRNB1-to-partner and partner-to-CHRNB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by CHRNB1-low versus CHRNB1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHRNB1→partner) and Y-score (partner→CHRNB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.510	+1.415	.022	.046	3	2
UCEC	eEF2 →	+0.269	+1.415	.045	.046	3	1
UCEC	EGFR_pY1068 →	-0.264	-2.169	.005	.003	3	1
UCEC	ERK2 →	+0.180	+2.584	.012	.010	3	1
UCEC	Heregulin →	-0.126	-2.308	.006	.033	3	1
UCEC	INPP4B →	-0.279	-3.459	.021	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

Caspase-7-cleavedD198 by CHRNB1 expression — UCEC

Explore this box plot interactively →