CHRNB1

Across TCGA cell cohorts, CHRNB1 mutation is significantly associated with the drug of many other genes, with 29 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CHRNB1-associated genes across cancer lineages are Fedratinib, YM201636, and XMD13-2. Each is linked with CHRNB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CHRNB1-to-partner and partner-to-CHRNB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Fedratinib grouped by CHRNB1-low versus CHRNB1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHRNB1→partner) and Y-score (partner→CHRNB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Fedratinib →	+0.558	+2.652	.033	.045	3	1
LARGE_INTESTINE	YM201636 →	+0.557	+2.786	.012	.037	3	1
LARGE_INTESTINE	XMD13-2 →	+0.487	+2.652	.023	.045	3	1
LARGE_INTESTINE	CP466722 →	+0.410	+2.652	.038	.045	2	1
LARGE_INTESTINE	GSK2256098C →	+0.316	+2.906	.040	.033	1	2
LARGE_INTESTINE	Zoledronate →	+0.283	+2.649	.045	.046	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

Fedratinib by CHRNB1 expression — LARGE_INTESTINE

Explore this box plot interactively →