CHRNA9

Across TCGA patient cohorts, CHRNA9 mutation is significantly associated with the RNA expression of many other genes, with 2,483 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CHRNA9-associated genes across cancer lineages are RDM1P1, CENPS-CORT, and C16orf95. Each is linked with CHRNA9 in more than 2 cancer types. Because this analysis shows association rather than direction, both CHRNA9-to-partner and partner-to-CHRNA9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RDM1P1 grouped by CHRNA9-low versus CHRNA9-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHRNA9→partner) and Y-score (partner→CHRNA9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RDM1P1 →	+0.013	+3.862	<.001	.005	3	3
UCEC	CENPS-CORT →	+0.408	+3.616	<.001	.001	3	2
UCEC	C16orf95 →	+0.273	+2.439	.001	.001	3	2
SKCM	RN7SL74P →	+0.060	+2.697	<.001	<.001	3	2
UCEC	CENPU →	+0.870	+2.695	<.001	<.001	3	2
UCEC	NTAN1 →	+0.524	+2.716	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,483 associations by consensus.

RDM1P1 by CHRNA9 expression — SKCM

Explore this box plot interactively →