CHRNA9

Across TCGA patient cohorts, CHRNA9 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CHRNA9-associated genes across cancer lineages are Caspase-8, Lck, and PREX1. Each is linked with CHRNA9 in more than 1 cancer types. Because this analysis shows association rather than direction, both CHRNA9-to-partner and partner-to-CHRNA9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-8 grouped by CHRNA9-low versus CHRNA9-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHRNA9→partner) and Y-score (partner→CHRNA9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-8 →	-0.264	-3.558	.010	.002	3	2
SKCM	Lck →	-0.291	-2.392	.013	<.001	3	1
SKCM	PREX1 →	-0.262	-1.584	.022	.032	3	1
SKCM	Shc_pY317 →	+0.143	+1.874	.032	.047	3	1
SKCM	Bax →	-0.182	-1.362	.024	.035	3	1
SKCM	CDK1_pY15 →	+0.445	+3.599	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

Caspase-8 by CHRNA9 expression — UCEC

Explore this box plot interactively →