CHRNA9

Across TCGA cell cohorts, CHRNA9 mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible CHRNA9-associated genes across cancer lineages are SMIM9, PRR20B, and PRR20A. Each is linked with CHRNA9 in more than 1 cancer types. Because this analysis shows association rather than direction, both CHRNA9-to-partner and partner-to-CHRNA9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SMIM9 grouped by CHRNA9-low versus CHRNA9-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHRNA9→partner) and Y-score (partner→CHRNA9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	SMIM9 →	+0.186	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	PRR20B →	+0.159	+5.643	<.001	.002	3	1
BLOOD_Lymphoma	PRR20A →	+0.159	+5.643	<.001	.002	3	1
BLOOD_Lymphoma	KRTAP10-1 →	+0.039	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	PRR20D →	+0.159	+5.643	<.001	.002	3	1
BLOOD_Lymphoma	PRR20E →	+0.159	+5.643	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

SMIM9 by CHRNA9 expression — BLOOD_Lymphoma

Explore this box plot interactively →