CHRNA7

Across TCGA patient cohorts, CHRNA7 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CHRNA7-associated genes across cancer lineages are Notch1, EGFR_pY1068, and eIF4G. Each is linked with CHRNA7 in more than 1 cancer types. Because this analysis shows association rather than direction, both CHRNA7-to-partner and partner-to-CHRNA7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by CHRNA7-low versus CHRNA7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHRNA7→partner) and Y-score (partner→CHRNA7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.218	+3.183	<.001	.009	3	2
UCEC	EGFR_pY1068 →	-0.244	-2.000	.031	.032	3	1
UCEC	eIF4G →	+0.391	+3.321	.005	.010	3	1
UCEC	ERK2 →	+0.217	+2.000	.012	.032	3	1
UCEC	Gab2 →	+0.383	+2.700	.017	.006	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.495	+2.000	.030	.032	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

Notch1 by CHRNA7 expression — UCEC

Explore this box plot interactively →