CHRNA7

Across TCGA cell cohorts, CHRNA7 mutation is significantly associated with the drug of many other genes, with 25 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CHRNA7-associated genes across cancer lineages are BIX02189, Niraparib, and Leflunomide. Each is linked with CHRNA7 in more than 1 cancer types. Because this analysis shows association rather than direction, both CHRNA7-to-partner and partner-to-CHRNA7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BIX02189 grouped by CHRNA7-low versus CHRNA7-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHRNA7→partner) and Y-score (partner→CHRNA7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	BIX02189 →	+0.461	+2.652	.021	.045	3	2
LARGE_INTESTINE	Niraparib →	+0.403	+2.646	.023	.047	3	1
LARGE_INTESTINE	Leflunomide →	+0.291	+2.769	.022	.040	3	1
LARGE_INTESTINE	615590 →	+0.338	+2.710	.017	.027	3	1
LARGE_INTESTINE	TAK-715 →	+0.421	+2.786	.044	.037	3	1
LARGE_INTESTINE	Quizartinib →	+0.330	+2.652	.041	.045	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

BIX02189 by CHRNA7 expression — LARGE_INTESTINE

Explore this box plot interactively →