CHRNA6

Across TCGA patient cohorts, CHRNA6 RNA expression is significantly associated with the protein abundance of many other proteins, with 10,066 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible CHRNA6-associated proteins across cancer lineages are ARHGAP45, TRIM22, and NFATC2. Each is linked with CHRNA6 in more than 5 cancer types. Because this analysis shows association rather than direction, both CHRNA6-to-partner and partner-to-CHRNA6 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CHRNA6 versus ARHGAP45 in GBM, with a Pearson correlation of 0.42.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (CHRNA6→partner) and Y-score (partner→CHRNA6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ARHGAP45 →	+0.490	+0.597	.002	.001	3	6
GBM	TRIM22 →	+0.512	+0.705	<.001	<.001	3	5
LSCC	NFATC2 →	+0.480	+0.694	<.001	<.001	3	5
GBM	CD74 →	+0.588	+0.650	<.001	.001	3	5
GBM	GGA2 →	+0.292	+0.669	.001	<.001	3	5
LSCC	GIMAP1 →	+0.592	+0.429	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,066 associations by consensus.

CHRNA6 vs ARHGAP45 — GBM

Explore this scatter interactively →