CHRNA6

Across TCGA patient cohorts, CHRNA6 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CHRNA6-associated genes across cancer lineages are Cyclin-B1, Shc_pY317, and STAT3_pY705. Each is linked with CHRNA6 in more than 2 cancer types. Because this analysis shows association rather than direction, both CHRNA6-to-partner and partner-to-CHRNA6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by CHRNA6-low versus CHRNA6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHRNA6→partner) and Y-score (partner→CHRNA6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.528	+2.169	.012	.003	3	3
UCEC	Shc_pY317 →	-0.114	-1.415	.044	.046	3	2
UCEC	STAT3_pY705 →	-0.329	-1.896	<.001	.015	3	2
UCEC	ATM →	-0.357	-1.415	.036	.046	3	2
UCEC	14-3-3_beta →	-0.081	-2.432	.032	.018	3	1
UCEC	EGFR →	-0.151	-2.973	.011	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

Cyclin-B1 by CHRNA6 expression — UCEC

Explore this box plot interactively →