CHRNA6

Across TCGA cell cohorts, CHRNA6 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,095 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible CHRNA6-associated GO terms across cancer lineages are Regulation of post-translational protein modification, Protein localization to nucleus, and Spliceosomal complex assembly. Each is linked with CHRNA6 in more than 4 cancer types. Because this analysis shows association rather than direction, both CHRNA6-to-partner and partner-to-CHRNA6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of post-translational protein modification grouped by CHRNA6-low versus CHRNA6-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CHRNA6→partner) and Y-score (partner→CHRNA6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Regulation of post-translational protein modification →	+0.044	+0.031	<.001	.006	3	5
SKIN	Protein localization to nucleus →	+0.037	+0.674	.001	.003	3	5
LARGE_INTESTINE	Spliceosomal complex assembly →	+0.064	+0.031	<.001	.006	3	5
LARGE_INTESTINE	Transcription by RNA polymerase I →	+0.087	+0.032	<.001	.005	3	4
BLOOD_Leukemia	Regulation of macrophage colony-stimulating factor production →	-0.444	-0.357	.004	.008	3	4
BLOOD_Leukemia	Heart contraction →	-0.056	-0.493	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,095 associations by consensus.

Regulation of post-translational protein modification by CHRNA6 expression — LARGE_INTESTINE

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