CHRNA6

Across TCGA cell cohorts, CHRNA6 mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CHRNA6-associated genes across cancer lineages are PIWIL1, CBLIF, and OR7G3. Each is linked with CHRNA6 in more than 1 cancer types. Because this analysis shows association rather than direction, both CHRNA6-to-partner and partner-to-CHRNA6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PIWIL1 grouped by CHRNA6-low versus CHRNA6-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHRNA6→partner) and Y-score (partner→CHRNA6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PIWIL1 →	+0.059	+4.044	<.001	.004	3	1
BLOOD_Leukemia	CBLIF →	+0.081	+3.769	<.001	.008	3	1
BLOOD_Leukemia	OR7G3 →	+0.027	+4.384	<.001	.006	3	1
BLOOD_Leukemia	OR1N2 →	+0.037	+3.705	<.001	.007	3	1
BLOOD_Leukemia	OR10Q1 →	+0.019	+4.384	<.001	.006	3	1
BLOOD_Leukemia	ATP4B →	+0.871	+3.855	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

PIWIL1 by CHRNA6 expression — BLOOD_Leukemia

Explore this box plot interactively →