CHRNA5

Across TCGA pan-cancer cohorts, CHRNA5 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated CHRNA5 data layer compared with 23 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher CHRNA5 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated CHRNA5 expression acts as an unfavorable survival marker, although some lineages such as ESCA and UCEC show a favorable association.

SKCM, ESCA, and UCEC are the cancer types where CHRNA5 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	III,IV	0.288	0.710	.002	12	view →
ESCA	DFS	Median	II,III,IV	0.511	0.358	<.001	10	view →
UCEC	DFS	Median	All	0.955	0.621	.023	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

CHRNA5–SKCM (OS)

Open the SKCM breakdown →