CHRNA5

Across TCGA patient cohorts, CHRNA5 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CHRNA5-associated genes across cancer lineages are Annexin_VII, C-Raf, and Di-Ras3. Each is linked with CHRNA5 in more than 1 cancer types. Because this analysis shows association rather than direction, both CHRNA5-to-partner and partner-to-CHRNA5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Annexin_VII grouped by CHRNA5-low versus CHRNA5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHRNA5→partner) and Y-score (partner→CHRNA5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Annexin_VII →	-0.140	-3.160	.020	.019	3	2
UCEC	C-Raf →	+0.171	+2.000	.006	.030	3	2
UCEC	Di-Ras3 →	-0.147	-3.156	.023	.018	3	2
UCEC	EGFR_pY1068 →	-0.268	-2.115	.014	.019	3	1
UCEC	FoxM1 →	+0.224	+3.906	.048	<.001	3	1
UCEC	Ku80 →	+0.232	+1.598	.024	.044	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

Annexin_VII by CHRNA5 expression — UCEC

Explore this box plot interactively →