CHRNA5

Across TCGA cell cohorts, CHRNA5 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,517 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CHRNA5-associated GO terms across cancer lineages are DNA replication initiation, Mitotic DNA replication, and Positive regulation of cell cycle. Each is linked with CHRNA5 in more than 16 cancer types. Because this analysis shows association rather than direction, both CHRNA5-to-partner and partner-to-CHRNA5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA replication initiation grouped by CHRNA5-low versus CHRNA5-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CHRNA5→partner) and Y-score (partner→CHRNA5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	DNA replication initiation →	+0.162	+1.183	.005	.002	3	17
SKIN	Mitotic DNA replication →	+0.142	+1.135	<.001	<.001	3	16
OESOPHAGUS	Positive regulation of cell cycle →	+0.074	+1.081	.002	.002	3	15
OESOPHAGUS	DNA replication →	+0.092	+1.091	.004	.001	2	16
OESOPHAGUS	DNA-templated DNA replication →	+0.098	+1.026	.003	.003	2	16
SKIN	Sister chromatid segregation →	+0.091	+0.878	.002	.002	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,517 associations by consensus.

DNA replication initiation by CHRNA5 expression — BONE

Explore this box plot interactively →