CHRNA5

Across TCGA cell cohorts, CHRNA5 mutation is significantly associated with the RNA expression of many other genes, with 18 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CHRNA5-associated genes across cancer lineages are SLC5A7, C1QTNF8, and ATP1B4. Each is linked with CHRNA5 in more than 1 cancer types. Because this analysis shows association rather than direction, both CHRNA5-to-partner and partner-to-CHRNA5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC5A7 grouped by CHRNA5-low versus CHRNA5-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHRNA5→partner) and Y-score (partner→CHRNA5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SLC5A7 →	+0.006	+4.922	<.001	.009	3	1
BLOOD_Leukemia	C1QTNF8 →	+0.028	+5.201	<.001	.006	3	1
BLOOD_Lymphoma	ATP1B4 →	+0.082	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	CRYGD →	+0.078	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	ZIC3 →	+0.522	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	NLRP8 →	+0.041	+4.867	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

SLC5A7 by CHRNA5 expression — BLOOD_Leukemia

Explore this box plot interactively →