CHRNA4

Across TCGA patient cohorts, CHRNA4 protein abundance is significantly associated with the RNA expression of many other genes, with 253 significant associations in total. GBM shows the largest number of these associations.

The most reproducible CHRNA4-associated genes across cancer lineages are PIEZO1, CHST7, and FUT6. Each is linked with CHRNA4 in more than 1 cancer types. Because this analysis shows association rather than direction, both CHRNA4-to-partner and partner-to-CHRNA4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CHRNA4 versus PIEZO1 in GBM, with a Pearson correlation of 0.78.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHRNA4→partner) and Y-score (partner→CHRNA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PIEZO1 →	+0.883	+0.369	.008	.008	3	1
GBM	CHST7 →	+1.080	+0.369	.008	.008	3	1
GBM	FUT6 →	+0.142	+0.369	.005	.008	3	1
GBM	MBL2 →	+0.050	+0.541	.006	<.001	3	1
GBM	MS4A15 →	+0.113	+0.369	.003	.008	3	1
GBM	CXCL8 →	+2.312	+0.369	.009	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 253 associations by consensus.

CHRNA4 vs PIEZO1 — GBM

Explore this scatter interactively →