CHRNA4

Across TCGA patient cohorts, CHRNA4 mutation is significantly associated with the RNA expression of many other genes, with 3,195 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CHRNA4-associated genes across cancer lineages are ZNF330, DLGAP5, and TAF13. Each is linked with CHRNA4 in more than 4 cancer types. Because this analysis shows association rather than direction, both CHRNA4-to-partner and partner-to-CHRNA4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNF330 grouped by CHRNA4-low versus CHRNA4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHRNA4→partner) and Y-score (partner→CHRNA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ZNF330 →	+0.335	+2.447	.004	.001	3	5
STAD	DLGAP5 →	+0.756	+3.459	.007	.005	3	4
UCEC	TAF13 →	+0.582	+3.010	<.001	<.001	3	4
UCEC	SRP54 →	+0.412	+3.043	.003	<.001	3	4
SKCM	MFN2 →	+0.376	+1.974	.006	.008	3	4
UCEC	DHDDS →	+0.333	+1.617	<.001	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,195 associations by consensus.

ZNF330 by CHRNA4 expression — UCEC

Explore this box plot interactively →