CHRNA4

Across TCGA cell cohorts, CHRNA4 RNA expression is significantly associated with the go_rna of many other GO terms, with 896 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible CHRNA4-associated GO terms across cancer lineages are Regulation of translation at synapse, modulating synaptic transmission, Positive regulation of DNA metabolic process, and Aldosterone biosynthetic process. Each is linked with CHRNA4 in more than 4 cancer types. Because this analysis shows association rather than direction, both CHRNA4-to-partner and partner-to-CHRNA4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of translation at synapse, modulating synaptic transmission grouped by CHRNA4-low versus CHRNA4-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CHRNA4→partner) and Y-score (partner→CHRNA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Regulation of translation at synapse, modulating synaptic transmission →	+0.120	+0.120	<.001	.001	3	5
SOFT_TISSUE	Positive regulation of DNA metabolic process →	+0.047	+0.401	.001	.002	3	5
SOFT_TISSUE	Aldosterone biosynthetic process →	+0.887	+0.448	<.001	<.001	3	5
SOFT_TISSUE	Regulation of sodium ion transport →	-0.075	-0.445	<.001	.002	3	5
LUNG_NSCLC_LUSC	Negative regulation of gene expression, epigenetic →	+0.052	+0.085	.004	.008	3	4
SOFT_TISSUE	Keratinocyte proliferation →	-1.082	-0.345	<.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 896 associations by consensus.

Regulation of translation at synapse, modulating synaptic transmission by CHRNA4 expression — LUNG_NSCLC_LUSC

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