CHRNA4

Across TCGA cell cohorts, CHRNA4 mutation is significantly associated with the RNA expression of many other genes, with 40 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CHRNA4-associated genes across cancer lineages are RBMY1J, GAGE12D, and GAGE12C. Each is linked with CHRNA4 in more than 1 cancer types. Because this analysis shows association rather than direction, both CHRNA4-to-partner and partner-to-CHRNA4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RBMY1J grouped by CHRNA4-low versus CHRNA4-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHRNA4→partner) and Y-score (partner→CHRNA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	RBMY1J →	+0.006	+4.977	<.001	.007	3	2
BLOOD_Myeloma	GAGE12D →	+2.469	+3.906	.001	.009	3	1
BLOOD_Myeloma	GAGE12C →	+2.381	+3.906	<.001	.009	3	1
BLOOD_Myeloma	AMY1A →	+0.069	+3.906	<.001	.009	3	1
STOMACH	IL36A →	+0.030	+4.544	.001	<.001	3	1
LARGE_INTESTINE	CRYBB1 →	+0.559	+2.556	.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

RBMY1J by CHRNA4 expression — SKIN

Explore this box plot interactively →