CHRNA3

Across TCGA patient cohorts, CHRNA3 RNA expression is significantly associated with the protein abundance of many other proteins, with 15,018 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible CHRNA3-associated proteins across cancer lineages are MYEF2, RAB34_S244, and MTA1_S576. Each is linked with CHRNA3 in more than 4 cancer types. Because this analysis shows association rather than direction, both CHRNA3-to-partner and partner-to-CHRNA3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CHRNA3 versus MYEF2 in LSCC, with a Pearson correlation of 0.53.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (CHRNA3→partner) and Y-score (partner→CHRNA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MYEF2 →	+0.914	+0.601	<.001	<.001	3	5
COAD	RAB34_S244 →	+0.705	+0.980	<.001	<.001	3	4
LSCC	MTA1_S576 →	+0.670	+0.457	<.001	<.001	3	4
LSCC	PFN2 →	+0.727	+0.610	<.001	<.001	3	4
GBM	PLIN3 →	-0.485	-0.504	<.001	.004	3	4
UCEC	RCN2 →	+0.646	+1.450	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,018 associations by consensus.

CHRNA3 vs MYEF2 — LSCC

Explore this scatter interactively →