CHRNA3

Across TCGA patient cohorts, CHRNA3 mutation is significantly associated with the RNA expression of many other genes, with 1,728 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CHRNA3-associated genes across cancer lineages are MTND6P1, WASH9P, and ALKBH1. Each is linked with CHRNA3 in more than 1 cancer types. Because this analysis shows association rather than direction, both CHRNA3-to-partner and partner-to-CHRNA3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTND6P1 grouped by CHRNA3-low versus CHRNA3-high in LGG.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHRNA3→partner) and Y-score (partner→CHRNA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LGG	MTND6P1 →	+0.074	+7.977	<.001	.007	3	2
UCEC	WASH9P →	+0.395	+3.606	.003	.001	3	2
UCEC	ALKBH1 →	+0.321	+2.042	.007	.001	3	2
UCEC	E2F1 →	+0.829	+2.403	<.001	<.001	3	2
UCEC	PARD6A →	+0.864	+2.392	<.001	<.001	3	2
UCEC	OIP5 →	+0.645	+2.807	.003	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,728 associations by consensus.

MTND6P1 by CHRNA3 expression — LGG

Explore this box plot interactively →