CHRNA3

Across TCGA patient cohorts, CHRNA3 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CHRNA3-associated genes across cancer lineages are MAPK_pT202_Y204, 14-3-3_beta, and EGFR_pY1068. Each is linked with CHRNA3 in more than 1 cancer types. Because this analysis shows association rather than direction, both CHRNA3-to-partner and partner-to-CHRNA3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAPK_pT202_Y204 grouped by CHRNA3-low versus CHRNA3-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHRNA3→partner) and Y-score (partner→CHRNA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MAPK_pT202_Y204 →	+0.885	+3.000	<.001	.035	3	1
UCEC	14-3-3_beta →	-0.112	-3.432	.005	.005	3	1
UCEC	EGFR_pY1068 →	-0.243	-1.906	.016	.016	3	1
UCEC	ERK2 →	+0.225	+2.807	.003	.003	3	1
UCEC	GATA6 →	-0.130	-2.407	.037	.003	3	1
UCEC	ACC1 →	+0.287	+2.183	.049	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

MAPK_pT202_Y204 by CHRNA3 expression — SKCM

Explore this box plot interactively →