CHRNA3

Across TCGA cell cohorts, CHRNA3 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible CHRNA3-associated genes across cancer lineages are SIRPD, PPIAL4E, and HMHB1. Each is linked with CHRNA3 in more than 1 cancer types. Because this analysis shows association rather than direction, both CHRNA3-to-partner and partner-to-CHRNA3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SIRPD grouped by CHRNA3-low versus CHRNA3-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHRNA3→partner) and Y-score (partner→CHRNA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	SIRPD →	+0.058	+5.029	<.001	.006	3	1
LUNG_SCLC	PPIAL4E →	+0.036	+5.643	<.001	.002	3	1
LUNG_NSCLC_LUAD	HMHB1 →	+0.108	+5.662	<.001	.002	3	1
LUNG_NSCLC_LUAD	GSX1 →	+0.122	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	OR6M1 →	+0.034	+5.228	.002	.005	3	1
LUNG_NSCLC_LUAD	GLT6D1 →	+0.006	+5.662	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

SIRPD by CHRNA3 expression — LUNG_SCLC

Explore this box plot interactively →