CHRNA3

Across TCGA cell cohorts, CHRNA3 mutation is significantly associated with the mutation status of many other genes, with 515 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CHRNA3-associated genes across cancer lineages are MAGEB1, PSMD8, and DNAAF1. Each is linked with CHRNA3 in more than 2 cancer types. Because this analysis shows association rather than direction, both CHRNA3-to-partner and partner-to-CHRNA3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAGEB1 grouped by CHRNA3-low versus CHRNA3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHRNA3→partner) and Y-score (partner→CHRNA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MAGEB1 →	+5.523	+5.523	.003	.003	1	3
BLOOD_Leukemia	PSMD8 →	+5.870	+4.894	<.001	<.001	1	3
LUNG_SCLC	DNAAF1 →	+5.502	+5.502	.003	.003	1	2
LUNG_SCLC	ZNF583 →	+4.502	+5.066	.007	.007	1	2
LARGE_INTESTINE	BAD →	+5.523	+5.523	.003	.003	1	2
LARGE_INTESTINE	RNASET2 →	+5.523	+5.523	.003	.003	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 515 associations by consensus.

MAGEB1 by CHRNA3 expression — LARGE_INTESTINE

Explore this box plot interactively →