CHRNA2

Across TCGA patient cohorts, CHRNA2 mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CHRNA2-associated genes across cancer lineages are mTOR_pS2448, PCNA, and Rictor_pT1135. Each is linked with CHRNA2 in more than 2 cancer types. Because this analysis shows association rather than direction, both CHRNA2-to-partner and partner-to-CHRNA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by CHRNA2-low versus CHRNA2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHRNA2→partner) and Y-score (partner→CHRNA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	mTOR_pS2448 →	-0.197	-2.321	.012	.033	3	3
COAD	PCNA →	+0.266	+3.008	.038	.019	3	2
UCEC	Rictor_pT1135 →	-0.090	-2.584	.018	.010	3	2
UCEC	STAT3_pY705 →	-0.450	-2.502	<.001	.001	3	2
UCEC	ATM →	-0.620	-3.687	<.001	.001	3	2
UCEC	Caspase-8 →	-0.285	-3.880	.002	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

mTOR_pS2448 by CHRNA2 expression — SKCM

Explore this box plot interactively →