CHRNA10

Across TCGA patient cohorts, CHRNA10 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CHRNA10-associated genes across cancer lineages are Chk1, IGFBP2, and MSH2. Each is linked with CHRNA10 in more than 1 cancer types. Because this analysis shows association rather than direction, both CHRNA10-to-partner and partner-to-CHRNA10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Chk1 grouped by CHRNA10-low versus CHRNA10-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHRNA10→partner) and Y-score (partner→CHRNA10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Chk1 →	+0.273	+2.841	.018	.035	3	2
UCEC	IGFBP2 →	-1.052	-3.321	<.001	.010	3	1
UCEC	MSH2 →	-0.312	-3.160	.003	.019	3	1
UCEC	p70-S6K →	+0.176	+1.901	.049	.031	3	1
UCEC	C-Raf →	+0.156	+3.000	.019	.036	3	1
UCEC	ARID1A →	-0.204	-2.577	.016	.011	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Chk1 by CHRNA10 expression — SKCM

Explore this box plot interactively →