CHRNA10

Across TCGA cell cohorts, CHRNA10 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,147 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CHRNA10-associated GO terms across cancer lineages are Regulation of mRNA splicing, via spliceosome, DNA integrity checkpoint signaling, and Signal transduction in response to DNA damage. Each is linked with CHRNA10 in more than 14 cancer types. Because this analysis shows association rather than direction, both CHRNA10-to-partner and partner-to-CHRNA10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of mRNA splicing, via spliceosome grouped by CHRNA10-low versus CHRNA10-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CHRNA10→partner) and Y-score (partner→CHRNA10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Regulation of mRNA splicing, via spliceosome →	+0.086	+0.315	<.001	<.001	3	15
BONE	DNA integrity checkpoint signaling →	+0.104	+0.470	.008	.006	3	15
BONE	Signal transduction in response to DNA damage →	+0.079	+0.458	<.001	<.001	3	15
STOMACH	Telomere tethering at nuclear periphery →	+0.134	+0.407	<.001	.003	3	14
SKIN	Subtelomeric heterochromatin formation →	+0.093	+0.367	<.001	<.001	3	14
LARGE_INTESTINE	Cell cycle checkpoint signaling →	+0.072	+0.590	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,147 associations by consensus.

Regulation of mRNA splicing, via spliceosome by CHRNA10 expression — SOFT_TISSUE

Explore this box plot interactively →