CHRNA10

Across TCGA cell cohorts, CHRNA10 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CHRNA10-associated genes across cancer lineages are KRTAP13-2, CYYR1, and PROKR1. Each is linked with CHRNA10 in more than 1 cancer types. Because this analysis shows association rather than direction, both CHRNA10-to-partner and partner-to-CHRNA10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP13-2 grouped by CHRNA10-low versus CHRNA10-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHRNA10→partner) and Y-score (partner→CHRNA10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	KRTAP13-2 →	+0.039	+5.029	<.001	.006	3	1
LARGE_INTESTINE	CYYR1 →	+0.023	+4.256	<.001	.002	3	1
LARGE_INTESTINE	PROKR1 →	+0.045	+3.426	.001	.007	3	1
LARGE_INTESTINE	PRAMEF20 →	+0.008	+3.700	<.001	.009	3	1
LARGE_INTESTINE	OR2J1 →	+0.002	+3.700	<.001	.009	3	1
LARGE_INTESTINE	C16orf96 →	+0.522	+3.520	.003	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

KRTAP13-2 by CHRNA10 expression — LUNG_SCLC

Explore this box plot interactively →